Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer

Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer }:{ My August 2007 stem cell transplant (SCT) was done with adult cells from an unrelated donor.  While the procedure is fraught with risks, mortality, and morbidity factors for the recipient, an SCT or the BMT (bone marrow) equivalent is virtually harmless to the adult donor.
 }:{  alt@search  }:{  alt@story   }:{ 

Because I was the recipient of life-saving stem cells 5.8 years ago, I am naturally more than a casual observer of the science.  But everyone who seriously follows this story line and these tweets, realizes that society and medicine at large both face certain ethical questions regarding transplants using embryonic cells.  While the adult cells issue is largely resolved, I am not sure that this “breakthrough” cloning of embryonic cells solves the larger ethical issue, but it does bring the science to an important threshold, thanks to the work of:

Shoukhrat Mitalipov is an associate scientist in the Division of Reproductive & Developmental Sciences of ONPRC, Oregon Stem Cell Center and Departments of Obstetrics & Gynecology and Molecular & Medical Genetics, and co-director of the ART/ESC core at the Center. He earned his Ph.D. degree in Developmental & Stem Cell Biology at the Research Center for Medical Genetics in Moscow, Russia. He came to Utah State University in 1995 to conduct his postdoctoral research in stem cell and developmental biology. Dr. Mitalipov moved to the Oregon center in 1998.

In summary, the research by Dr. Mitalipov deals with totipotent and pluripotent stem cells that are important as a unique research tool that allows investigation of the mechanisms regulating early primate development and differentiation. Human stem cells also provide the far-reaching foundation for the field of regenerative medicine and offer hope for the treatment of a wide range of clinical conditions that can be attributed to the loss or malfunction of specific cell types. Translational research in the clinically relevant nonhuman primate model is highly desirable to evaluate the safety, feasibility and efficacy of cell-based therapies. The basic research conducted in the Mitalipov lab provides new insights into the generation, maintenance and developmental potential of primate totipotent and pluripotent stem cells.

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Timekeeping in the SCT zone

If there has been a lesson and, of course, there have been many that came out of the ocurrence of mantle cell lymphoma (MCL) in 2006, it is that time-keeping has a necessary, but continuous presence.

As of this post, we mark 68 months since my successful stem cell transplant.  That’s 5.66 years or 1833 days.  Does that mean we are cured?

Of course, we hope and pray that is the case, but none of my doctors will proclaim a cure.  Never, for the remainer of my life, can we expect that certainty.  Yet, survival is good and the best outcome of all.  What is it they say about not focusing on the destination, but enjoying the journey?

Dee Dee and I along with our friends Larry Fetters and Kathy Wright spent several hours at City of Hope yesterday (May 10) for the 37th annual BMT Reunion with an estimated 5000 participants. Gathered in Duarte were those BMT and SCT survivors like me (since Aug. 22, 2007). Just a few yards away was the Helford Hospital where my transplant was performed.  As the crowds assembled on the hospital’s north lawn, probably about three dozen transplant patients occupied beds waiting for the day they could also celebrate with us.

Below, Dee Dee and I pose with my chief oncologist Dr. Ryotaro Nakamura. Just a fabulous day to share with the celebrating crowd of survivors, their caregivers, friends, and loved ones. }:{  alt@LINK  }:{  This link provides a slide show of our day.


 

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Reading for a Transplanted Life

Now loaded on my Nexus7 KINDLE app is THE HEALING CELL, touted as an easy to read, carefully researched, and clear-eyed view of medicine many decades in the making. Cancer-free stem cell transplant patients like me know this truth about stem cells that are now paying off with treatments that repair damaged hearts, restore sight, kill cancer, cure diabetes, heal burns, and stop the march of such degenerative diseases as Alzheimer’s, multiple sclerosis, Lou Gehrig’s disease, and (in my case) mantle cell lymphoma.

The emotionally and intellectually stimulating stories throughout the book dramatically illustrate that stem cell therapies can change the way we live our lives after being afflicted by a disease or trauma. The book is the result of a unique collaboration between the Vatican’s Pontifical Council for Culture and the Stem for Life Foundation. It includes a special address by former Pope Benedict XVI, urging increased support and awareness for advancements in adult stem cell research.

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Reading for a Transplanted Life

Survivor : She showed me, not she can show you

Roslyn Franken is a proud young adult cancer survivor who knows the power of emotional resilience in the face of change, challenge and adversity. She was born to a mother who survived the concentration camps in Nazi Germany and a father who survived the atomic bomb in Nagasaki, Japan, as a prisoner of war.

When diagnosed with Hodgkin’s Lymphoma cancer at the young of age 29, Roslyn quickly learned she inherited her parents’ “NEVER GIVE UP” attitude as she herself fought back to become a long-term survivor.

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Also see : exit Everything ||  HALLMARKS  ||  Our SCT Xperience
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Survivor : She showed me, now she can show you

6 years since our SCT at COH

This coming Friday, May 10, will mark our return to City of Hope, Durate, CA, for the sixth reunion of SCT (stem cell transplant) patients like me. Not surprising is the fact that this is actually the 37th such reunion at the internationally-renowned cancer treatment and research center.

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and publisher of alt@cities on paper.li for
constant web and mobile communication
Also see : exit Everything ||  HALLMARKS  ||  Our SCT Xperience
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When you change the way you look at things, the things you look at change

6 years since our SCT at COH